How Does Medication For ADHD Work? The stimulants are among the most frequently ADHD drugs prescribed. They work by increasing the levels of brain chemicals known as dopamine and norepinephrine. They include the methylphenidate (Ritalin, Concerta), amphetamine and dextroamphetamine (Adderall) and Lisdexafetamine (Vyvanse). These are typically prescribed in long-release formulation